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Volume 1

PART I. PERSPECTIVES 1. Milestones in the History of Pulmonary Medicine, Alfred P. Fishman

PART II. SCIENTIFIC BASIS OF LUNG FUNCTION IN HEALTH AND DISEASE Section One. Architecture for Normal Lung Function 2. Functional Design of the Human Lung for Gas Exchange, Matthias Ochs & Ewald R. Weibel 3.The Respiratory Muscles, Marc Decramer 4. The Genetic, Molecular, and Cellular Basis of Lung Development, Stijn DeLanghe, Pierre Del Moral, Denise Tefft, Saverio Bellusci, & David Warburton 5. Development and Growth of the Lung, Johannes C. Schittny & Peter H. Burri 6. Cellular and Molecular Mechanisms Regulating Airway Smooth Muscle Physiology and Pharmacology, Reynold A. Panettieri, Jr. 7. Pulmonary Surfactant System and Alveolar Homeostasis, Jeffrey A. Whitsett & Ann D. Horowitz 8. Transport Function of Airway Epithelia and Submucosal Glands, Paul B. McCray, Jr. & Michael J. Walsh Section Two. Physiological Principles of Normal Lung Function 9. Pulmonary Mechanics, Murray D. Altose 10. Control of Ventilation, Neil S. Cherniack 11. Ventilation, Pulmonary Blood Flow, and Ventilation-Perfusion Relationships, Peter D. Wagner 12. Diffusion, Chemical Reactions, and Diffusing Capacity, Robert A. Klocke 13. Blood-Gas Transport, Michael P. Hlastala, Erik R. Swenson, & Robert A. Klocke 14. Acid-Base Balance, Stanley Goldfarb & Kumar Sharma
Section Three. The Lungs in Different Physiological States 15.Exercise, Integration, and Adaptation, Alfred P. Fishman 16. Breathing in Exercise, Brian J. Whipp & Susan A. Ward 17.The Lungs in Pregnancy, Daniel B. Rosenbluth & John Popovish, Jr. 18.Aging of the Respiratory System, Edward J. Campbell Section Four. Lung Immunology 19. Pulmonary Defense Mechanisms against Infections, Herbert Y. Reynolds and Jack A. Elias 20. Lymphocyte- and Macrophage-Mediated Inflammation in the Lung, Frederic F. Little, Kevin C. Wilson, Jeffrey S. Berman, and David M. Center 21. Mast Cells and Eosinophils, Edward S. Schulman and Peter H.S. Sporn 22. Antibody-Mediated Lung Defenses and Humoral Immunodeficiency, David N. Weissman, Kenneth S. Landreth, and Nevin W. Wilson Section Five. Lung Injury and Repair 23. Cytokines and Chemokines in Lung Inflammation and Injury, Robert M. Strieter, John A. Belperio, and Michael P. Keane 24. Leukocyte Accumulation in Pulmonary Disease, Nicholas W. Lukas and Peter A. Ward 25. Oxidative and Nitrosative Lung Injury, John D. Lang, Jr., Ian C. Davis, Rakesh P. Patel, and Sadis Matalon 26. The Pathogenesis of Pulmonary Fibrosis, Moises Selman & Annie Pardo

PART III. SYMPTOMS AND SIGNS OF RESPIRATORY DISEASE Section Six. Clinical Approach to the Patient 27. Approach to the Patient with Respiratory Symptoms, Darren B. Taichman and Alfred P. Fishmana 28. Skin Disease in Patients with Pulmonary Disease, Jeffrey P. Callen 29. Pulmonary-Systemic Interactions, Alfred P. Fishman Section Seven. Diagnostic Procedures 30. Radiographic Evaluation of the Chest, Wallace T. Miller 31. Pulmonary Cytopathology, Prabodh K. Gupta and Zubair W. Baloch 32. Interventional Radiology in the Thorax: Nonvascular and Vascular Applications, Aalpen A. Patel and Scott O. Trerotola 33. Scintigraphic Evaluation of Pulmonary Disease, Abass Alavi, Daniel F. Worsley, and Ghassan El-Haddad 34.Pulmonary Function Testing, Michael A. Grippi and Gregory Tino 35. Principles and Applications of Cardiopulmonary Exercise Testing, Karl T. Weber and Ahmad Munir 36. Bronchoscopy, Transthoracic Needle Aspiration, and Related Procedures, Anil Vachani, Luis Seijo, Michael Unger, and Daniel Sterman 37. Thoracoscopy, Larry R. Kaiser 38. Perioperative Respiratory Considerations, Horace M. DeLisser and Michael A. Grippi 39. Evaluation of Impairment and Disability Due to Lung Disease, Paul E. Epstein

PART IV. OBSTRUCTIVE LUNG DISEASES Section Eight. Chronic Obstructive Pulmonary Disease 40. Pathologic Features of Chronic Obstructive Pulmonary Disease: Diagnostic Criteria and Differential Diagnosis, Joanne L. Wright and Andrew Churg 41. Chronic Obstructive Pulmonary Disease: Epidemiology Pathophysiology, and Pathogenesis, Robert M. Senior and Jeffrey J. Atkonson 42.Chronic Obstructive Pulmonary Disease: Clinical Course and Management, Robert A. Wise 43. Cigarette Smoking and Disease, Stephen. I. Rennard, Lisa M. Hepp, and David M. Daughton 44. Rehabilitation in Chronic Obstructive Pulmonary Disease and Other Respiratory Disorders, Andrew L. Ries Section Nine: Asthma 45. The Biology of Asthma, Sameer K. Mathur and William W. Busse 46. Asthma: Epidemiology, Andrea J. Apter and Scott T. Weiss 47. Aspirin- and Exercise-Induced Asthma, Gregory P. Geba 48.Asthma: Clinical Presentation and Management, Rodolfo M. Pascual, JeRay J. Johnson, and Stephen P. Peteres 49. Allergic Bronchopulmonary Aspergillosis (Mycosis), Geoffrey Chupp and Carolyn L. Rochester Section Ten:Other Obstructive Disorders 50. Upper Airway Obstruction in Adults, Sidney S. Braman and Muhanned A. Abu-Hijleh 51. Cystic Fibrosis, Judith Voynow and Thomas F. Scanlin 52. Bronchiolitis, Talmadge E. King, Jr. and Brent W. Kinder 53. Bullous Disease of the Lungs, David M.F. Murphy and Alfred P. Fishman

PART V. OCCUPATIONAL AND ENVIRONMENTAL DISORDERS Section Eleven: Occupational and Environmental Disorders 54. Occupational Lung Disorders: General Principles and Approaches, Mridu Gulati and Carrie A. Redlich 55. Asbestos-Related Lung Disease, William N. Rom 56. Chronic Beryllium Disease and Hard-Metal Lung Diseases, Mary Elizabeth Kreider and Milton D. Rossman 57. Coal Workers¿ Lung Diseases and Silicosis, Edward L. Petsonk and John E. Parker 58. Occupational Asthma, Byssinosis, and Industrial Bronchitis, J. Allen D. Cooper, Jr. 59.Acute and Chronic Responses to Toxic Inhalations, Robert P. Dickson and David A. Schwartz Section Twelve. Environmental Disorders 60. Indoor and Outdoor Air Pollution, Jonathan M. Samet and Mark J. Utell 61. High Altitude Physiology and Clinical Disorders, Sukhamay Lahiri, Santhosh M. Baby, and Camillo DiGiulio 62. Diving Injuries and Air Embolism, James A. Clark 63. Thermal Lung Injury and Acute Smoke Inhalation, Daniel L. Traber and Perenlei Enkhbaatar

PART VI: DRUG-INDUCED LUNG DISEASES 64. Pulmonary Toxicity Associated with Chemotherepeutic Agents, Lynn T. Tanoue and John R. McArdle 65. Drug-Induced Lung Disease due to Nonchemotherapeutic Agents, Hilary C. Cain

PART VII: INTERSTITIAL AND INFLAMMATORY LUNG DISEASES Section Thirteen. Immunologic and Interstitial Diseases 66. Interstitial Lung Disease: A Clinical Overview and General Approach, Michael A. Nead and David G. Morris 67. Systemic Sarcoidosis, David R. Moller 68. Idiopathic Pulmonary Fibrosis, Eric B. Meltzer and Paul W. Noble 69. Hypersensitivity Pneumonitis, Richard I. Enelow 70. Radiation Pneumonitis, Kenneth B. Roberts and Sara Rockwell 71. Pulmonary Manifestations of the Collagen Vascular Diseases, Gregory P. Cosgrove and Marvin I. Schwarz 72. The Eosinophilic Pneumonias, Kristina Crothers and Carolyn L. Rochester Section Fourteen. Depositional and Infiltrative Disorders 73. Depositional Diseases of the Lungs, Robert J. Homer 74. Pulmonary Langerhan's-Cell Histiocytosis, Talmadge E. King, Jr. 75. Pulmonary Lymphangioleiomyomatosis, Talmadge E. King, Jr. 76. The Lungs in Patients with Inborn Errors of Metabolism, Masazuni Adachi and Francis A. Caccavo

PART VIII. ALVEOLAR DISEASES 77. Alveolar Hemorrhage Syndromes, Joseph P. Lynch, III and James W. Leatherman 78. Mechanisms of Aspiration Disorders, Richard D. Zorowitz 79. Pulmonary Alveolar Proteinosis, Bruce C. Trapnell and Jonathan Puchalski Appendixes Appendix A: Normal Values: Typical Values for a 20-Year-Old Seated Man Appendix B: Terms and Symbols in Respiratory Physiology Index Part Nine
DISORDERS OF THE PULMONARY CIRCULATION
Chapter 82
The Pulmonary Circulation
Chapter 83
Pulmonary Hypertension and Cor Pulmonale
Chapter 84
Pulmonary Thromboembolic Disease
Chapter 85
Pulmonary Edema
Chapter 86
Pulmonary Vasculitis
Chapter 87
Pulmonary Arteriovenous Malformations
Part Ten
DISORDERS OF THE PLEURAL SPACE
Chapter 88
Pleural Fluid Dynamics and Effusions
Chapter 89
Nonmalignant Pleural Effusions
Chapter 90
Malignant Pleural Effusions
Chapter 91
Pneumothorax
Chapter 92
Malignant Mesothelioma and Other Primary Pleural Tumors
Part Eleven
DISEASES OF THE MEDIASTINUM
Chapter 93
The Mediastinum: Overview, Anatomy, and Diagnostic Approach
Chapter 94
Nonneoplastic Disorders of the Mediastinum
Chapter 95
Congenital Cysts of the Mediastinum: Bronchopulmonary Foregut Anomalies
Chapter 96
Acquired Lesions of the Mediastinum: Benign and Malignant
Part Twelve
DISORDERS OF THE CHEST WALL, DIAPHRAGM, AND SPINE
Chapter 97
Nonmuscular Diseases of the Chest Wall
Chapter 98
Effects of Neuromuscular Diseases on Ventilation
Chapter 99
Pulmonary Rehabilitation in Neuromuscular Diseases
Part Thirteen
SLEEP AND SLEEP DISORDERS
Chapter 100
The Stages of Sleep
Chapter 101
Changes in the Cardiorespiratory System during Sleep
Chapter 102
Sleep Apnea Syndromes
Chapter 103
Differential Diagnosis and Evaluation of Sleepiness
Part Fourteen
SURGICAL ASPECTS OF PULMONARY MEDICINE
Chapter 104
Perioperative Care of the Patient Undergoing Lung Resection
Chapter 105
Thoracic Trauma
Chapter 106
Lung Transplantation
Part Fifteen
NEOPLASMS OF THE LUNGS
Section 15
Cancer of the Lungs
Chapter 107
Genetic and Molecular Changes of Human Lung Cancer
Chapter 108
Epidemiology of Lung Cancer
Chapter 109
Cigarette Smoking and Health Policy
Chapter 110
The Solitary Pulmonary Nodule: A Systemic Approach
Chapter 111
The Pathology of Non¿Small Cell Lung Carcinoma
Chapter 112
Non¿Small Cell Lung Cancer¿Clinical Aspects, Diagnosis, Staging, and Natural History
Chapter 113
Part I: Treatment of Non¿Small Cell Lung Cancer: Surgical
Part II: Treatment of Non¿Small Cell Lung Cancer: Chemotherapy
Part III: Treatment of Non¿Small Cell Lung Cancer: Radiation Therapy
Chapter 114
Small Cell Lung Cancer: Diagnosis, Treatment, and Natural History
Chapter 115
Primary Lung Tumors Other Than Bronchogenic Carcinoma: Benign and Malignant
Chapter 116
Extrapulmonary Syndromes Associated with Lung Tumors
Chapter 117
Pulmonary Metastases
Section 16
Lymphoproliferative Disorders
Chapter 118
Lymphoproliferative and Hematologic Diseases Involving the Lung
Part Sixteen
INFECTIOUS DISEASES OF THE LUNGS
Section 17
General Issues
Chapter 119
Microbial Flora and Colonization of the Respiratory Tract
Chapter 120
Pulmonary Clearance of Infectious Agents
Chapter 121
Approach to the Patient with Pulmonary Infections
Chapter 122
Principles of Antibiotic Use and the Selection of Empiric Therapy for Pneumonia
Chapter 123
Local Therapy and Pharmacokinetics of Antibiotics in the Lungs
Chapter 124
Vaccination for Pulmonary Infections
Chapter 125
Microbial Virulence Factors in Pulmonary Infections
Section 18
Pulmonary Infectious Syndromes
Chapter 126
Infections of the Upper Respiratory Tract
Chapter 127
Acute Bronchitis and Community-Acquired Pneumonia
Chapter 128
Pneumonia in Childhood
Chapter 129
Aspiration Disease and Anaerobic Infection
Chapter 130
Empyema and Lung Abscess
Chapter 131
Mediastinitis
Chapter 132
Bronchiectasis
Chapter 133
Systemic Infection, the Sepsis Syndrome, and the Lungs
Section 19
Special Hosts and Opportunistic Infections
Chapter 134
Introduction: Pulmonary Infection in Special Hosts
Chapter 135
HIV Infection and Opportunistic Pulmonary Infections in AIDS
Chapter 136
Pulmonary Infections in Neutropenia and Cancer
Chapter 137
Respiratory Disease in Bone Marrow and Hematopoietic Stem Cell Transplantation
Chapter 138
Pneumonia in the Organ Transplant Patient
Chapter 139
Pulmonary Infections in Patients with Primary Immune Defects
Chapter 140
Postoperative Pneumonia
Chapter 141
Respiratory Infections in the Economically Disadvantaged
Section 20
Specific Microorganisms
Chapter 142
Pneumonias Caused by Gram-Positive Bacteria
Chapter 143
Nosocomial Respiratory Tract Infections and Gram-Negative Pneumonia
Chapter 144
Legionellosis
Chapter 145
Mycoplasma, Chlamydia, and ¿Atypical Pneumonias¿
Chapter 146
Actinomycosis and Nocardiosis
Chapter 147
Aspergillus Syndromes, Mucormycosis,and Pulmonary Candidiasis
Chapter 148
Endemic Mycoses of North America: Histoplasmosis, Coccidioidomycosis, and Blastomycosis
Chapter 149
Cryptococcal Infections
Chapter 150
Pneumocystis Carinii
Chapter 151
Viral Infections of the Lung and Respiratory Tract
Chapter 152
The Lung in Human Immunodeficiency Virus Infection
Chapter 153
Emerging Infectious Diseases and Hantavirus Pulmonary Syndromev Chapter 154
Poliovirus and Other Enterovirus Infections
Chapter 155
Protozoan Infections of the Thorax
Chapter 156
Helminthic Diseases of the Lungs
Chapter 157
Zoonotic and Other Unusual Bacterial Pneumonias
Section 21
Mycobacterial Infections
Chapter 158
The Epidemiology, Transmission, and Prevention of Tuberculosis in the United States
Chapter 159
The Microbiology of the Mycobacteria
Chapter 160
Pathogenesis of Pulmonary Tuberculosis
Chapter 161
Screening for Tuberculosis and Tuberculosis Infection in High-Risk Populations
Chapter 162
Clinical Presentation and Treatment of Tuberculosis
Chapter 163
Mycobacterial Infections and HIV Infection
Chapter 164
Diseases due to Mycobacteria Other than Mycobacterium Tuberculosis
Part Seventeen
ACUTE RESPIRATORY FAILURE
Section 22
Lung Failure
Chapter 165
Respiratory Failure: An Overview
Chapter 166
Acute Respiratory Distress Syndrome:Pathogenesis
Chapter 167
Acute Respiratory Distress Syndrome: Clinical Features, Management, and Outcome
Chapter 168
The Systemic Inflammatory Response Syndrome and the Multiple Organ Dysfunction Syndrome
Chapter 169
Respiratory Distress Syndrome in Premature Newborn Infants
Chapter 170
Acute Respiratory Failure in the Surgical Patient
Section 23
Respiratory Pump Failure
Chapter 171
Pump Failure: The Pathogenesis of Hypercapnic Respiratory Failure in Patients with Lung and Chest Wall Disease
Section 24
Management and Therapeutic Interventions
Chapter 172
Oxygen Therapy and Pulmonary Oxygen Toxicity
Chapter 173
Pulmonary Pharmacotherapy
Chapter 174
Intubation and Upper Airway Management
Chapter 175
Hemodynamic and Respiratory Monitoring in Acute Respiratory Failure
Chapter 176
Mechanical Ventilation: Conventional Modes and Settings
Chapter 177
Mechanical Ventilation: Physiological Considerations and New Ventilatory Techniques
Chapter 178
Nutrition in Acute Respiratory Failure
Chapter 179
Treatment of Agitation and Distress in Mechanically Ventilated Patients
Chapter 180
Decision Making in the Intensive Care Unit
Chapter 181
Ethics in the Intensive Care Unit
Chapter 182
Prevention and Control of Lung Disease
APPENDIXES
Appendix A
Respiratory Questionnaire
Appendix B
Normal Values B-1
Appendix C
Terms and Symbols in Respiratory Physiology C-1
INDEX I-1